Exosomal long noncoding RNA MLETA1 promotes tumor progression and metastasis by regulating the miR-186-5p/EGFR and miR-497-5p/IGF1R axes in non-small cell lung cancer.

Xiu-Rui HsuJia-En WuYi-Ying WuSheng-Yen HsiaoJui-Lin LiangYa-Ju WuChia-Hao TungMeng-Fan HuangMing-Shiu LinPan-Chyr YangYuh-Ling ChenTse-Ming Hong

Published in: Journal of experimental & clinical cancer research : CR (2023)

This study identifies lnc-MLETA1 as a critical exosomal lncRNA that mediates crosstalk in lung cancer cells to promote cancer metastasis and may serve as a prognostic biomarker and potential therapeutic target for lung cancer diagnosis and treatment.

Keyphrases

long noncoding rna
small cell lung cancer
papillary thyroid
epidermal growth factor receptor
poor prognosis
tyrosine kinase
genome wide
squamous cell
squamous cell carcinoma
long non coding rna
binding protein
pi k akt
young adults
dna methylation
human health
risk assessment
signaling pathway