Circular RNAs in the Origin of Developmental Lung Disease: Promising Diagnostic and Therapeutic Biomarkers.
Yajie TongShuqing ZhangSuzette RiddleRui SongDongmei YuePublished in: Biomolecules (2023)
Circular RNA (circRNA) is a newly discovered noncoding RNA that regulates gene transcription, binds to RNA-related proteins, and encodes protein microRNAs (miRNAs). The development of molecular biomarkers such as circRNAs holds great promise in the diagnosis and prognosis of clinical disorders. Importantly, circRNA-mediated maternal-fetus risk factors including environmental (high altitude), maternal (preeclampsia, smoking, and chorioamnionitis), placental, and fetal (preterm birth and low birth weight) factors are the early origins and likely to contribute to the occurrence and progression of developmental and pediatric cardiopulmonary disorders. Although studies of circRNAs in normal cardiopulmonary development and developmental diseases have just begun, some studies have revealed their expression patterns. Here, we provide an overview of circRNAs' biogenesis and biological functions. Furthermore, this review aims to emphasize the importance of circRNAs in maternal-fetus risk factors. Likewise, the potential biomarker and therapeutic target of circRNAs in developmental and pediatric lung diseases are explored.
Keyphrases
- preterm birth
- low birth weight
- risk factors
- birth weight
- gestational age
- preterm infants
- pregnancy outcomes
- human milk
- poor prognosis
- genome wide
- case control
- early onset
- machine learning
- pregnant women
- risk assessment
- big data
- human health
- small molecule
- single cell
- dna methylation
- physical activity
- smoking cessation
- copy number
- body mass index
- single molecule
- climate change
- deep learning