The Hippo pathway effectors YAP and TAZ interact with EGF-like signaling to regulate expansion-related events in bovine cumulus cells in vitro.

Júlia KochValério Marques PortelaEsdras Corrêa Dos SantosDaniele MissioLeonardo Guedes de AndradeZigomar da SilvaBernardo Garziera GasperinAlfredo Quites AntoniazziPaulo Bayard Dias GonçalvesGustavo Zamberlam

Published in: Journal of assisted reproduction and genetics (2022)

Taken together, the results presented herein represent considerable insight into the functional relevance of a completely novel signaling pathway underlying cumulus expansion and oocyte maturation in monovulatory species. YAP/TAZ or CTGF may represent potential targets to improve the efficiency of IVM systems, not only for monovulatory species of agricultural importance as the cow, but for human embryo production.

Keyphrases

induced apoptosis
signaling pathway
endothelial cells
cell cycle arrest
pi k akt
human health
risk assessment
induced pluripotent stem cells
climate change
oxidative stress
genetic diversity
growth factor
heavy metals
cell death
pluripotent stem cells
pregnant women
drug induced