A novel chalcone derivative has antitumor activity in melanoma by inducing DNA damage through the upregulation of ROS products.
Keke LiShuang ZhaoJing LongJuan SuLisha WuJuan TaoJianda ZhouJiangLin ZhangXiang ChenCong PengPublished in: Cancer cell international (2020)
Taken together, we found that lj-1-59 treatment inhibits melanoma cell growth by inducing apoptosis and DNA damage through increased ROS levels, suggesting that this compound is a potential therapeutic drug for melanoma treatment.