A novel chalcone derivative has antitumor activity in melanoma by inducing DNA damage through the upregulation of ROS products.

Keke LiShuang ZhaoJing LongJuan SuLisha WuJuan TaoJianda ZhouJiangLin ZhangXiang ChenCong Peng

Published in: Cancer cell international (2020)

Taken together, we found that lj-1-59 treatment inhibits melanoma cell growth by inducing apoptosis and DNA damage through increased ROS levels, suggesting that this compound is a potential therapeutic drug for melanoma treatment.

Keyphrases

dna damage
oxidative stress
cell death
dna repair
signaling pathway
skin cancer
poor prognosis
cell cycle arrest
drug induced