Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation.
Charlotte KingAmanda McKennaNiloufar FarzanSusanne J VijverbergMarc P van der ScheeAnke H Maitland-van der ZeeLambang AriantoHans BisgaardKlaus BØnnelykkeVojko BerceUros PotoČnikKatja RepnikBruce CarletonDenise DaleyFook Tim ChewWen Chin ChiangYang Yie SioMichelle M CloutierHerman T Den DekkerLiesbeth DuijtsJohan C de JongsteF Nicole DijkCarlos FloresNatalia Hernandez-PachecoSomnath MukhopadhyayKaninika BasuKelan G TantisiraKatia M VerhammeJuan C CeledónErick FornoGlorisa CaninoBen FrancisMunir PirmohamedIan SinhaDaniel B HawcuttPublished in: The pharmacogenomics journal (2020)
A systematic review of pharmacogenomic studies capturing adverse drug reactions (ADRs) related to asthma medications was undertaken, and a survey of Pharmacogenomics in Childhood Asthma (PiCA) consortia members was conducted. Studies were eligible if genetic polymorphisms were compared with suspected ADR(s) in a patient with asthma, as either a primary or secondary outcome. Five studies met the inclusion criteria. The ADRs and polymorphisms identified were change in lung function tests (rs1042713), adrenal suppression (rs591118), and decreased bone mineral density (rs6461639) and accretion (rs9896933, rs2074439). Two of these polymorphisms were replicated within the paper, but none had external replication. Priorities from PiCA consortia members (representing 15 institution in eight countries) for future studies were tachycardia (SABA/LABA), adrenal suppression/crisis and growth suppression (corticosteroids), sleep/behaviour disturbances (leukotriene receptor antagonists), and nausea and vomiting (theophylline). Future pharmacogenomic studies in asthma should collect relevant ADR data as well as markers of efficacy.
Keyphrases
- lung function
- adverse drug
- chronic obstructive pulmonary disease
- electronic health record
- cystic fibrosis
- air pollution
- case control
- systematic review
- bone mineral density
- allergic rhinitis
- clinical decision support
- postmenopausal women
- randomized controlled trial
- drug induced
- physical activity
- body composition
- public health
- current status
- pulmonary embolism
- data analysis
- deep learning
- artificial intelligence
- catheter ablation