Reliability and Reproducibility of Absolute Myocardial Blood Flow: Does It Depend on the PET/CT Technology, the Vasodilator, and/or the Software?
K Lance GouldLinh BuiDanai KitkungvanMonica B PatelPublished in: Current cardiology reports (2021)
Comprehensive, integrated, myocardial perfusion quantified by regional pixel distribution of coronary flow capacity (CFC) is the final common expression of objective CAD severity for which revascularization reduces mortality. Current lack of revascularization benefit derives from narrow thinking focused on measuring one isolated aspect of coronary characteristics, such as angiogram stenosis, its fractional flow reserve (FFR), anatomic FFR simulations, relative stress imaging, absolute stress ml/min/g or coronary flow reserve (CFR) alone, or even more narrowly on global CFR or fixed regions of interest in assumed coronary artery distributions, or in arbitrary 17 segments on bull's-eye displays, rather than regional pixel distribution of perfusion metrics as they actually are in an individual. Comprehensive integration of all quantitative perfusion metrics per regional pixel into coronary flow capacity guides artery-specific interventions for reduced mortality in non-acute CAD but requires addressing the methodologic questions in the title.
Keyphrases
- coronary artery
- coronary artery disease
- pet ct
- cardiovascular events
- percutaneous coronary intervention
- blood flow
- coronary artery bypass grafting
- pulmonary artery
- high resolution
- poor prognosis
- liver failure
- physical activity
- type diabetes
- aortic stenosis
- cardiovascular disease
- molecular dynamics
- positron emission tomography
- pulmonary hypertension
- intensive care unit
- aortic valve
- transcatheter aortic valve replacement
- aortic dissection
- drug induced