HSP90 Inhibitor Ganetespib (STA-9090) Inhibits Tumor Growth in c-Myc-Dependent Esophageal Squamous Cell Carcinoma.
Liuliu GuanQingqing ZouQian LiuYiguang LinSize ChenPublished in: OncoTargets and therapy (2020)
In conclusion, our data support that the HSP90 inhibitor, STA-9090, suppresses the expression of the MYC protein and interferes with HSP90-MYC protein-protein interaction. This, in turn, leads to inhibition of ESCC cell proliferation and promotion of apoptosis in ESCC cells in vitro and reduction of ESCC tumors in vivo. We propose, based on our findings, that STA-9090 is a potential novel therapeutic target for MYC-positive ESCC.
Keyphrases
- protein protein
- heat shock protein
- cell cycle arrest
- heat shock
- small molecule
- heat stress
- cell proliferation
- transcription factor
- induced apoptosis
- pi k akt
- cell death
- oxidative stress
- endoplasmic reticulum stress
- poor prognosis
- signaling pathway
- electronic health record
- living cells
- sensitive detection
- risk assessment
- climate change
- long non coding rna
- data analysis
- quantum dots
- deep learning