Asymmetric crypt fission in sessile serrated lesions.

Published in: Journal of clinical pathology (2020)

SSL-ND thrive with crypts in asymmetric fission displaying randomly distributed proliferating cell-domains and maspin-upregulation. These histo-biological aberrations disclose pathological cryptogenesis and suggest possibly unfolding somatic mutations in SSL-ND. The present findings may open new vistas on the parameters pertinent to the susceptibility of SSL-ND to develop dysplasia and carcinoma.

Keyphrases

copy number
single cell
minimally invasive
solid state
cell therapy
cell proliferation
poor prognosis
stem cells
genome wide