Effect of focal adhesion kinase inhibition on osteoblastic cells grown on titanium with different topographies.
Helena Bacha LopesAlann Thaffarell Portilho SouzaGileade Pereira FreitasCarlos Nelson EliasAdalberto Luiz RosaAdalberto Luiz RosaPublished in: Journal of applied oral science : revista FOB (2020)
Our data demonstrate the relevance of FAK in the interactions between osteoblastic cells and Ti surfaces regardless of surface topography. Nanotopography positively regulated FAK expression and integrin signaling pathway components during osteoblast differentiation. In this context, the development of Ti surfaces with the ability to upregulate FAK activity could positively impact the process of implant osseointegration.