Asymmetric Transfer Hydrogenation of Densely Functionalized Diheteroaryl and Diaryl Ketones by a Ru-Catalyst of Minimal Stereogenicity.
Dongxu HeXingjun XuYi LuMin-Jie ZhouXiangyou XingPublished in: Organic letters (2020)
A highly enantioselective asymmetric transfer hydrogenation (ATH) of densely functionalized diheteroaryl and diaryl ketones was developed using Ru-catalysts of minimal stereogenicity. Various ketone substrates with structurally and electronically similar groups attached to the prochiral centers were reduced successfully in good to excellent enantioselectivities and yields. This protocol provides practical and efficient access to chiral diheteroarylmethanols and benzhydrols, which are key intermediates in pharmaceuticals and biologically active compounds.
Keyphrases
- highly efficient
- quantum dots
- ionic liquid
- energy transfer
- randomized controlled trial
- molecularly imprinted
- metal organic framework
- solid state
- room temperature
- reduced graphene oxide
- electron transfer
- capillary electrophoresis
- carbon dioxide
- transition metal
- high resolution
- tandem mass spectrometry
- simultaneous determination