Characterising sex differences of autosomal DNA methylation in whole blood using the Illumina EPIC array.

Olivia A GrantYucheng WangMeena KumariNicolae Radu ZabetLeonard Schalkwyk

Published in: Clinical epigenetics (2022)

Our study reports a reliable catalogue of sex-associated CpG sites and elucidates several characteristics of these sites using large-scale discovery and validation data sets. This resource will benefit future studies aiming to investigate sex specific epigenetic signatures and further our understanding of the role of DNA methylation in sex differences in human whole blood.

Keyphrases

dna methylation
genome wide
gene expression
endothelial cells
high throughput
small molecule
copy number
electronic health record
current status
machine learning
pluripotent stem cells
high density
high throughput sequencing