Epigenome-Wide Meta-Analysis Reveals Associations Between Dietary Glycemic Index and Glycemic Load and DNA Methylation in Children and Adolescents of Different Body Sizes.

Raffael OttRobert SteinHelena H Hauta-AlusJustiina RonkainenSílvia Fernández-BarrésUlrike SpielauHolger KirstenTanja PoulainPhillip E MeltonLeanne K KüpersHatim AzaryahMarco ColomboKathrin LandgrafElmar W TobiTherese O'SullivanRae-Chi HuangCristina CampoyChristiane WinklerJesus VioqueMartine VrijheidWieland KiessAntje KörnerSylvain SebertMarjo-Riitta JarvelinAnette-G ZieglerSandra Hummel

Published in: Diabetes care (2023)

We identified 537 associations between dietary GI and GL and blood DNAm, mainly in children and adolescents with overweight or obesity. High-GI and/or -GL diets may influence epigenetic gene regulation and thereby promote metabolic derangements in young people with increased BMI.

Keyphrases

dna methylation
weight loss
type diabetes
weight gain
systematic review
genome wide
gene expression
glycemic control
insulin resistance
body mass index
metabolic syndrome
meta analyses
physical activity
copy number
randomized controlled trial
nk cells