Randomised, placebo-controlled trial and meta-analysis show benefit of ondansetron for irritable bowel syndrome with diarrhoea: The TRITON trial.
David GunnRabia TopanLorna BarnardRon FriedIvana HollowayRichard BrindleMaura CorsettiMark ScottAdam FarmerKapil KapurDavid SandersMaria EugenicosNigel TrudgillPeter WhorwellJohn T McLaughlinAyesha AkbarLesley A HoughtonPhil G DinningQasim AzizAlexander Charles FordAmanda J FarrinRobin C SpillerPublished in: Alimentary pharmacology & therapeutics (2023)
Although small numbers meant the primary endpoint was not met in this trial, when pooled with other similar trials meta-analysis suggests ondansetron improves stool consistency and reduces days with loose stool and urgency. Trial registration - http://www.isrctn.com/ISRCTN17508514.