Which prognostic marker is responsible for the clinical heterogeneity in CLL with 13q deletion?

Beyhan Durak ArasSevgi IsikHava Uskudar TekeAbdulvahap AslanFiliz YavasogluZafer GulbasFatih DemirkanHulya OzenOguz CilingirNur Sena InciGulcin GundenTuba BuldukEbru Erzurumluoglu GokalpSinem KocagilSevilhan ArtanOlga Meltem Akay

Published in: Molecular cytogenetics (2021)

The statistical analysis of our data regarding to the association between RB1 deletion and deletion type, TTFT, disease stage, and OS has not confirmed type II deletion or biallelic deletion cause poor prognosis. However, our data supports the deletion burden has a prognostic effect. More studies are needed to elucidate the cause of the clinical heterogeneity of CLL cases with del(13q).

Keyphrases

poor prognosis
long non coding rna
single cell
big data
intellectual disability
deep learning
artificial intelligence