Clinical and Prognostic Implications of 1p/19q, IDH, BRAF, MGMT Promoter, and TERT Promoter Alterations, and Expression of Ki-67 and p53 in Human Gliomas.
Zixi YangFeng LingSibei RuanJiajia HuMingxi TangXingwang SunWenbo LongPublished in: Cancer management and research (2021)
IDH-mu only and quadruple-positivity were associated with good OS in glioma patients, while TERTp-mu only, TERTp-mu/MGMTp-M and p53+/Ki-67+ were associated with poor prognosis. Combining these genomic alterations and Ki-67/p53 expression should have clinical value in gliomas.
Keyphrases
- poor prognosis
- long non coding rna
- high grade
- dna methylation
- low grade
- neoadjuvant chemotherapy
- ejection fraction
- gene expression
- endothelial cells
- transcription factor
- newly diagnosed
- helicobacter pylori
- prognostic factors
- helicobacter pylori infection
- radiation therapy
- induced pluripotent stem cells
- rectal cancer