Early decreased neutrophil responsiveness is related to late onset sepsis in multitrauma patients: An international cohort study.
Kathelijne M GroeneveldLeo KoendermanBrian L WarrenSaskia JolLuke P H LeenenFalco HietbrinkPublished in: PloS one (2017)
Low responsiveness of neutrophils for the innate stimulus fMLF immediately after trauma preceded the development of septic shock during admission by almost a week and did not depend on a geographical/racial background, hospital protocols and health care facilities. Decreased neutrophil responsiveness appears to be a prerequisite for septic shock after trauma. This might enable anticipation of this severe complication in trauma patients.
Keyphrases
- septic shock
- trauma patients
- late onset
- healthcare
- early onset
- end stage renal disease
- ejection fraction
- immune response
- newly diagnosed
- chronic kidney disease
- prognostic factors
- intensive care unit
- peritoneal dialysis
- randomized controlled trial
- patient reported outcomes
- african american
- social media
- adverse drug
- health insurance