Treating Early Undifferentiated Arthritis: A Systematic Review and Meta-Analysis of Direct and Indirect Trial Evidence.

Maria Angeles Lopez-OlivoVoke Kakpovbia-EshareturiJude K A des BordesAndrea BarboRobin Christensen Maria E Suarez-Almazor

Published in: Arthritis care & research (2018)

Treating patients with UA resulted in a statistically significant delay in the development of RA, with the largest effect observed for methotrexate. These findings suggest that there is a window of opportunity to treat patients with UA early, to delay subsequent progression to RA.

Keyphrases

rheumatoid arthritis
disease activity
clinical trial
ankylosing spondylitis
study protocol
high dose
randomized controlled trial
interstitial lung disease
systemic sclerosis