MRI-Based Radiotherapy Planning to Reduce Rectal Dose in Excess of Tolerance.
Daniel R SchmidtMandar BhagwatDaniel I GlazerMing-Hui ChenMaryam MoteabbedElizabeth McMahonMarian J LoffredoClare M TempanyAnthony V D'AmicoPublished in: Prostate cancer (2022)
Using MRI to plan prostate IG-IMRT to a dose of 79.2 Gy reduces the volume of rectum receiving radiation dose in excess of tolerance (70 Gy or more) and should be considered in men who are at high risk for late rectal toxicity and are not good candidates for other rectal sparing techniques such as hydrogel spacer. This trial is registered with NCT02470910.
Keyphrases
- rectal cancer
- contrast enhanced
- magnetic resonance imaging
- locally advanced
- prostate cancer
- diffusion weighted imaging
- early stage
- drug delivery
- clinical trial
- radiation therapy
- oxidative stress
- phase iii
- computed tomography
- benign prostatic hyperplasia
- robot assisted
- randomized controlled trial
- phase ii
- hyaluronic acid
- double blind
- oxide nanoparticles