Regional Brain and Spinal Cord Volume Loss in Spinocerebellar Ataxia Type 3.
Jennifer FaberTamara SchaprianKoyak BerkanKathrin ReetzMarcondes Cavalcante FrançaThiago Junqueira Ribeiro de RezendeJiang HongWeihua LiaoBart van de WarrenburgJudith van GaalenAlexandra DurrFanny MochelPaola GiuntiHector Garcia-MorenoLudger SchoelsHolger HengelMatthis SynofzikBenjamin BenderGulin OzJames JoersJereon J de VriesJun-Suk KangDagmar Timmann-BraunHeike JacobiJon InfanteRichard JoulesSandro RomanzettiJorn DiedrichsenMatthias SchmidRobin WolzThomas KlockgetherPublished in: Movement disorders : official journal of the Movement Disorder Society (2021)
Regional brain and spinal cord tissue loss in spinocerebellar ataxia type 3 starts before ataxia onset. Pontine volume appears to be the most promising imaging biomarker candidate for interventional trials that aim at slowing the progression of spinocerebellar ataxia type 3. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.