Login / Signup

Sequence of androgen receptor-targeted vaccination with androgen deprivation therapy affects anti-prostate tumor efficacy.

Anusha MuralidharMelissa Gamat-HuberSita VakkalankaDouglas G McNeel
Published in: Journal for immunotherapy of cancer (2024)
Vaccination prior to ADT significantly improved antitumor responses, mediated in part by increased infiltration of CD8+T cells following ADT. Targeting MDSC recruitment following ADT further enhanced antitumor responses. These findings suggest logical directions for future clinical trials to improve the efficacy of prostate cancer vaccines.
Keyphrases
  • prostate cancer
  • clinical trial
  • cancer therapy
  • radical prostatectomy
  • stem cells
  • randomized controlled trial
  • current status
  • benign prostatic hyperplasia
  • amino acid
  • double blind
  • replacement therapy