Development of mesoporous magnetic nanoparticles supported idarubicin and investigation of apoptotic and cytotoxic effects on cancer cell lines.
Hasan UlusalFatma UlusalNalan ÖzdemirPublished in: Molecular biology reports (2024)
Our study demonstrates that the effectiveness of idarubicin can be significantly enhanced by its application with mesoporous nanocarriers. This enhancement is attributed to the controlled release of idarubicin from the nanocarrier, which circumvents drug resistance mechanisms, improves drug solubility, and increases the drug-carrying capacity per unit volume due to the porous structure of the carrier. These findings underscore the potential of the synthesized nanocarrier in cancer treatment and provide a clear direction for future research in this field.
Keyphrases
- drug delivery
- magnetic nanoparticles
- metal organic framework
- randomized controlled trial
- papillary thyroid
- systematic review
- highly efficient
- cell death
- cancer therapy
- adverse drug
- drug release
- drug induced
- current status
- squamous cell carcinoma
- emergency department
- anti inflammatory
- risk assessment
- tissue engineering
- lymph node metastasis