Implantable Electronic Medicine Enabled by Bioresorbable Microneedles for Wireless Electrotherapy and Drug Delivery.
Ya HuangHu LiTianli HuJian LiChun Ki YiuJingkun ZhouJiyu LiXingcan HuangKuanming YaoXiao QiuYu ZhouDengfeng LiBinbin ZhangRui ShiYiming LiuTsz Hung WongMengge WuHuiling JiaZhan GaoZhibiao ZhangJiahui HeMengjia ZhengEnming SongLidai WangChenjie XuXinge YuPublished in: Nano letters (2022)
A combined treatment using medication and electrostimulation increases its effectiveness in comparison with one treatment alone. However, the organic integration of two strategies in one miniaturized system for practical usage has seldom been reported. This article reports an implantable electronic medicine based on bioresorbable microneedle devices that is activated wirelessly for electrostimulation and sustainable delivery of anti-inflammatory drugs. The electronic medicine is composed of a radio frequency wireless power transmission system and a drug-loaded microneedle structure, all fabricated with bioresorbable materials. In a rat skeletal muscle injury model, periodic electrostimulation regulates cell behaviors and tissue regeneration while the anti-inflammatory drugs prevent inflammation, which ultimately enhance the skeletal muscle regeneration. Finally, the electronic medicine is fully bioresorbable, excluding the second surgery for device removal.
Keyphrases
- skeletal muscle
- anti inflammatory drugs
- drug delivery
- stem cells
- randomized controlled trial
- insulin resistance
- systematic review
- minimally invasive
- healthcare
- emergency department
- single cell
- adverse drug
- cancer therapy
- type diabetes
- metabolic syndrome
- coronary artery disease
- adipose tissue
- cell therapy
- coronary artery bypass
- low cost
- atrial fibrillation