FAT4 loss initiates hepatocarcinogenesis through the switching of canonical to noncanonical WNT signaling pathways.
Fung-Yu HuangDanny Ka-Ho WongLoey Lung-Yi MakTan-To CheungSai-Sai ZhangHau-Tak ChauRex Wan-Hin HuiWai Kay SetoMan Fung YuenPublished in: Hepatology communications (2023)
Our data show that FAT4 loss is sufficient to drive HCC development through the switching of canonical to noncanonical Wingless-type signaling pathways. The findings may provide a mechanistic basis for an in-depth study of the two pathways in the early and late stages of HCC for precise treatment.