Dupilumab-associated ocular surface disease is characterized by a shift from Th2/Th17 toward Th1/Th17 inflammation.
Kathrin ThormannAnne-Sophie LüthiFelix DeniauAnja HeiderSimone CazzanigaSusanne Radonjic-HoesliMathias LehmannChristoph SchlapbachElio L HerzogMarco KreuzerMartin Sebastian ZinkernagelMübeccel AkdisDenise C Zysset-BurriHans-Uwe SimonDagmar SimonPublished in: Allergy (2024)
DAOSD is characterized by a Th1/Th17 cytokine profile and an upregulation of markers known to promote remodeling and fibrosis. The expression pattern of inflammatory markers in tear fluids at baseline might serve as a prognostic factor for DAOSD.