A Network Pharmacology Approach to Predict the Proangiogenesis Mechanism of Huangqi-Honghua Herb Pair after Cerebral Ischemia.

Jinyi CaoLu LeiKai WangJing SunYi QiaoJialin DuanChao ZhaoJia CuiZhijun FengJing-Wen WangAidong WenZhifu Yang

Published in: Evidence-based complementary and alternative medicine : eCAM (2021)

Our results predict that HH may regulate the expression of VEGFA, VEGFR2, and eNOS via the VEGF and HIF-1 signaling pathway to promote angiogenesis and alleviate cerebral ischemia injury.

Keyphrases

cerebral ischemia
endothelial cells
vascular endothelial growth factor
subarachnoid hemorrhage
blood brain barrier
brain injury
signaling pathway
pi k akt
poor prognosis
nitric oxide synthase
cell proliferation
nitric oxide
induced apoptosis
network analysis