Prediction of Disease Progression and Clinical Response in Systemic Sclerosis: Experience From a Proof-of-Concept Trial.

Marta NevePaul M DiderichsenEric HelmerDick de VriesAmit Taneja

Published in: ACR open rheumatology (2024)

Disease progression and drug effect could be predicted beyond the range of observed data. This modeling and simulation approach may inform future trial design, including study duration, and predict the probability of success.

Keyphrases

systemic sclerosis
interstitial lung disease
phase iii
study protocol
clinical trial
phase ii
electronic health record
randomized controlled trial
big data
drug induced
double blind