Expression of AR-V7 and ARv567es in Circulating Tumor Cells Correlates with Outcomes to Taxane Therapy in Men with Metastatic Prostate Cancer Treated in TAXYNERGY.
Scott T TagawaEmmanuel S AntonarakisAda GjyreziGiuseppe GallettiSeaho KimDaniel WorrollJohn StewartAtef ZaherTed P SzatrowskiKarla V BallmanKatsuhiro KitaShinsuke TasakiYang BaiLuigi PortellaBrian J KirbyFred SaadMario A EisenbergerDavid M NanusParaskevi GiannakakouPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
Although detection of both CTC-specific AR-V7 and ARv567es by ddPCR influenced taxane outcomes, AR-V7 primarily mediated the prognostic impact. The absence of both variants was associated with the best response and PFS with taxane treatment.See related commentary by Dehm et al., p. 1696.
Keyphrases
- circulating tumor cells
- prostate cancer
- metastatic breast cancer
- poor prognosis
- circulating tumor
- small cell lung cancer
- squamous cell carcinoma
- radical prostatectomy
- gene expression
- copy number
- type diabetes
- mesenchymal stem cells
- stem cells
- middle aged
- dna methylation
- long non coding rna
- replacement therapy
- binding protein
- quantum dots