Interleukin-18, IL-18 binding protein and IL-18 receptor expression in asthma: a hypothesis showing IL-18 promotes epithelial cell differentiation.

Davinder KaurLatifa ChachiEdith GomezNicolas SylviusChristopher E Brightling

Published in: Clinical & translational immunology (2021)

In asthma, the dynamic interaction between IL-18, its cognate receptor and natural inhibitor is complex, with differences between airway compartments. Upregulation of IL-18 can promote epithelial activation and cellular differentiation.

Keyphrases

binding protein
chronic obstructive pulmonary disease
lung function
signaling pathway
poor prognosis
cystic fibrosis
air pollution
allergic rhinitis
long non coding rna