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Allopurinol and cardiovascular events: Time-related biases in observational studies.

Samy SuissaKarine SuissaMarie Hudson
Published in: Arthritis care & research (2021)
Observational studies reporting significantly reduced incidence of cardiovascular events with allopurinol use were affected by time-related biases. Overall, studies that avoided these biases did not find a protective effect. The ALL-HEART randomised trial will provide important and accurate evidence on the potential effectiveness of allopurinol on cardiovascular outcomes.
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