Inhibition of TNFα-induced interleukin-6 gene expression by barley (Hordeum vulgare) ethanol extract in BV-2 microglia.
Jihye ChoiJuhwan KimDong Yeong MinEuitaek JungYoongho LimSoon Young ShinYoung Han LeePublished in: Genes & genomics (2019)
NF-κB-binding site within the IL-6 promoter region is a HVE target element involved in the inhibition of TNFα-induced IL-6 gene transcription. HVE inhibits TNFα-induced IL-6 expression via suppression of NF-κB signaling in BV2 microglial cells.
Keyphrases
- lps induced
- gene expression
- high glucose
- diabetic rats
- rheumatoid arthritis
- oxidative stress
- inflammatory response
- lipopolysaccharide induced
- signaling pathway
- drug induced
- induced apoptosis
- pi k akt
- transcription factor
- poor prognosis
- neuropathic pain
- spinal cord injury
- immune response
- cell cycle arrest
- endothelial cells
- cell death
- endoplasmic reticulum stress
- copy number