Phase II Clinical Trial of Intravenous Levothyroxine to Mitigate Pharyngocutaneous Fistula in Euthyroid Patients Undergoing Salvage Laryngectomy.

Molly E Heft Neal Catherine T Haring Emily Light Bellile Craig C Jaffe Andrew G Shuman Steven Bennett Chinn Chaz L Stucken Kelly M Malloy Keith A Casper Mark E P Prince Douglas B Chepeha Andrew J Rosko Matthew E Spector

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Postoperative intravenous levothyroxine supplementation reduced rates of acute hypothyroidism, fistula formation, and fistula requiring reoperation in patients undergoing salvage total laryngectomy without adverse effects. Intravenous levothyroxine is a viable strategy to reduce wound complications in this high-risk patient population.

Keyphrases

patients undergoing
phase ii
clinical trial
high dose
open label
phase iii
liver failure
double blind
case report
risk factors
randomized controlled trial
placebo controlled
intensive care unit
acute respiratory distress syndrome
wound healing
hepatitis b virus
smoking cessation