Minocycline alleviates nociceptive response through modulating the expression of NR2B subunit of NMDA receptor in spinal cord of rat model of painful diabetic neuropathy.

Che Aishah Nazariah Ismail Anis Kausar Ghazali Rapeah Suppian Che Badariah Ab Aziz Idris Long

Published in: Journal of diabetes and metabolic disorders (2021)

Minocycline alleviates nociceptive responses in PDN rats, possibly via suppression of NR2B activation. Therefore, minocycline could be one of the potential therapeutic antinociceptive drugs for the management of neuropathic pain.

Keyphrases

neuropathic pain
spinal cord
spinal cord injury
poor prognosis
mouse model
type diabetes
wound healing
anti inflammatory