Overexpression of Peroxiredoxin 3 in Cartilage Reduces the Severity of Age-Related Osteoarthritis But Not Surgically Induced Osteoarthritis in Mice.

Richard F LoeserPhilip R CoryellAlexandra R ArmstrongJohn A CollinsPriya GopalakrishnanKatie A McDermottQitao RanCathy S Carlson

Published in: ACR open rheumatology (2022)

Overexpression of the mitochondrial peroxidase Prx3 reduced the severity of age-related OA, but not at advanced ages and not in DMM-induced OA in younger mice.

Keyphrases

knee osteoarthritis
high glucose
diabetic rats
cell proliferation
transcription factor
drug induced
skeletal muscle