Safety, Tolerability, and Effects of Sodium Bicarbonate Inhalation in Cystic Fibrosis.

Carla Cristina Souza GomezPaloma Lopes Francisco ParazziKarl Jan ClinckspoorRenan Marrichi MauchFrancisco Benedito Teixeira PessineCarlos Emilio LevyAndressa Oliveira PeixotoMaria Ângela Gonçalves Oliveira RibeiroAntônio Fernando RibeiroDouglas ConradPaul Marquis QuintonFernando Augusto Lima MarsonJosé Dirceu Ribeiro

Published in: Clinical drug investigation (2020)

Nebulized NaHCO3 inhalation appears to be a safe and well tolerated potential therapeutic agent in the management of CF. Nebulized NaHCO3 inhalation temporarily elevates airway liquid pH and reduces sputum viscosity and viscoelasticity.

Keyphrases

cystic fibrosis
pseudomonas aeruginosa
lung function
open label
mycobacterium tuberculosis
ionic liquid
pulmonary tuberculosis
randomized controlled trial
clinical trial
chronic obstructive pulmonary disease
double blind
air pollution
study protocol