Primary Epithelioid Angiosarcoma of the Submandibular Gland-A Case Report with Histology-Cytology Correlation and Comprehensive Molecular Analysis.

Ming Liang OonBingcheng WuJian Yuan Goh Kenneth Tou-En ChangYan Ling ChongZi Wei WongShoo Yi OhCharmaine TanMin En NgaFredrik Petersson

Published in: Head and neck pathology (2024)

Epithelioid angiosarcoma is an important differential diagnosis to high-grade salivary gland carcinoma. In particular, GATA3 expression may be encountered in both angiosarcoma and high-grade salivary gland carcinomas and cause diagnostic confusion. Identification of TP53 mutations and CDKN2A losses suggest shared oncogenic pathways with soft tissue angiosarcomas, and should be further investigated.

Keyphrases

high grade
low grade
soft tissue
transcription factor
poor prognosis
atomic force microscopy
binding protein
mass spectrometry