miR-424: A novel potential therapeutic target and prognostic factor in malignancies.
Narges DastmalchiBehzad BaradaranSeyed Mahdi Banan KhojastehMohammadali HosseinpourfeiziReza SafaralizadehPublished in: Cell biology international (2020)
microRNAs are endogenous, noncoding RNAs. Showing both tumor-suppressive and oncogenic characteristics, miRNAs can regulate important processes in malignancies. This review aimed at highlighting the recent studies on the contribution of miR-424 to the modulation of carcinogenesis and exploring its probable clinical effectiveness in the diagnosis and therapy of malignancies. The data were extracted from all papers published from 2013 until 2020. Mature miR-424 leads to the degradation of its target transcripts or the suppression of translation via binding to the molecular targets. miR-424 is involved in modulating p53, PI3K/Akt, Wnt, and other molecular pathways, thereby regulating cellular growth, apoptosis, differentiation, chemoresistance, and cancer immunity. miR-424 was introduced as a tumor-suppressive miR in numerous types of cancers while as an oncogene in several cancers. Regarding the cancer dependent role of miR-424, it may be a prognostic and diagnostic biomarker and a potential candidate for the treatment of cancers.
Keyphrases
- cell proliferation
- long non coding rna
- long noncoding rna
- pi k akt
- systematic review
- stem cells
- cell cycle arrest
- randomized controlled trial
- transcription factor
- oxidative stress
- squamous cell carcinoma
- cell death
- climate change
- mesenchymal stem cells
- deep learning
- artificial intelligence
- replacement therapy
- meta analyses
- cancer stem cells