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Establishment and Characterization of a Tumor Stem Cell-Based Glioblastoma Invasion Model.

Stine Skov JensenMorten MeyerStine Asferg PettersonBo HalleAnn Mari RosagerCharlotte Aaberg-JessenMads ThomassenMark BurtonTorben A KruseBjarne Winther Kristensen
Published in: PloS one (2016)
The established invasion model kept in stem cell medium closely mimics tumor cell invasion into the brain in vivo preserving also to some extent the expression of stem cell markers. The model is feasible and robust and we suggest the model as an in vivo-like model with a great potential in glioma studies and drug discovery.
Keyphrases
  • stem cells
  • drug discovery
  • poor prognosis
  • mesenchymal stem cells
  • risk assessment
  • climate change
  • blood brain barrier
  • long non coding rna
  • white matter
  • bone marrow