Genome-wide profiling of histone H3K27 acetylation featured fatty acid signalling in pancreatic beta cells in diet-induced obesity in mice.
Takao NammoHaruhide UdagawaNobuaki FunahashiMiho KawaguchiTakashi UebansoMasaki HiramotoWataru NishimuraKazuki YasudaPublished in: Diabetologia (2018)
The next-generation sequencing data in the present study were deposited at ArrayExpress. RNA-Seq: Dataset name: ERR2538129 (Control), ERR2538130 (Diet-induced obesity) Repository name and number: E-MTAB-6718 - RNA-Seq of pancreatic islets derived from mice fed a long-term high-fat diet against chow-fed controls. ChIP-Seq: Dataset name: ERR2538131 (Control), ERR2538132 (Diet-induced obesity) Repository name and number: E-MTAB-6719 - H3K27ac ChIP-Seq of pancreatic islets derived from mice fed a long-term high-fat diet (HFD) against chow-fed controls.
Keyphrases
- high fat diet
- rna seq
- insulin resistance
- high fat diet induced
- single cell
- adipose tissue
- metabolic syndrome
- high throughput
- skeletal muscle
- genome wide
- type diabetes
- fatty acid
- dna methylation
- weight loss
- circulating tumor cells
- weight gain
- electronic health record
- copy number
- body mass index
- wild type
- machine learning
- gene expression
- data analysis
- artificial intelligence