Therapeutic role of deferred cytoreductive nephrectomy in patients with metastatic renal cell carcinoma treated with nivolumab plus ipilimumab.

Maki YoshinoHiroki IshiharaYuki NemotoKazutaka NakamuraKoichi NishimuraHidekazu TachibanaHironori FukudaDaisuke TokiKazuhiko YoshidaHirohito KobayashiJunpei IizukaHiroaki ShimmuraYasunobu HashimotoKazunari TanabeTsunenori KondoToshio Takagi

Published in: Japanese journal of clinical oncology (2022)

The present retrospective data showed that deferred cytoreductive nephrectomy had the potential to exert a therapeutic effect in a subset of patients who obtained favorable tumor responses to nivolumab plus ipilimumab for a certain period. Prospective randomized clinical trials are needed to confirm the prognostic impact of deferred cytoreductive nephrectomy after frontline immunotherapy in synchronous metastatic renal cell carcinoma.

Keyphrases

metastatic renal cell carcinoma
robot assisted
editorial comment
minimally invasive
cross sectional
big data
clinical trial
machine learning
newly diagnosed
human health
deep learning