Stroke Recovery in Rats after 24-Hour-Delayed Intramuscular Neurotrophin-3 Infusion.

Denise A DurickiSvetlana DrndarskiMichel BernanosTobias WoodKaren BoschQin ChenH David ShineCamilla SimmonsSteven C R WilliamsStephen B McMahonDavid J BegleyDiana CashLawrence David Falcon Moon

Published in: Annals of neurology (2018)

Our results show that delayed, peripheral infusion of NT3 can improve sensorimotor function after ischemic stroke. Phase I and II clinical trials of NT3 (for constipation and neuropathy) have shown that peripheral high doses are safe and well tolerated, which paves the way for NT3 as a therapy for stroke. ANN NEUROL 2019;85:32-46.

Keyphrases

atrial fibrillation
clinical trial
low dose
chemotherapy induced
randomized controlled trial
cerebral ischemia
irritable bowel syndrome
neural network
phase ii
subarachnoid hemorrhage
brain injury
placebo controlled