IL-10 and TGF-β unbalanced levels in neutrophils contribute to increase inflammatory cytokine expression in childhood obesity.
Nayara I MedeirosRafael T MattosCarlos A MenezesRafaelle C G FaresAndré TalvaniWalderez O DutraFabrício Rios-SantosRodrigo Correa-OliveiraJuliana de Assis Silva GomesPublished in: European journal of nutrition (2017)
The unbalance between the ratio of IL-10 and TGF-β expressions, the IL-10 lower expression, and changes in correlation profile seem to contribute with an inefficient regulation of inflammatory cytokine expression in childhood obesity. However, these changes still not may be considered the sole mechanism that directs inflammation during childhood obesity, once other molecules, pathways, and cells should be evaluated.