A Uniform Computational Approach Improved on Existing Pipelines to Reveal Microbiome Biomarkers of Nonresponse to Immune Checkpoint Inhibitors.
Fyza Y ShaikhJames R WhiteJoell J GillsTaiki HakozakiCorentin RichardBertrand RoutyYusuke OkumaMykhaylo UsykAbhishek PandeyJeffrey S WeberJiyoung AhnEvan J LipsonJarushka NaidooDrew M PardollCynthia L SearsPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Our analysis highlights the development of biomarkers for nonresponse, rather than response, in predicting ICI outcomes and suggests a new approach to identify patients who would benefit from microbiome-based interventions to improve response rates.