Cynthia L Sears

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 23

Top Topics

Clostridium Difficile

Chronic Rhinosinusitis

Top Venues

Cancer discovery

Microbiology spectrum

This page only lists publications with an associated author ORCID identifier.

Publications

Cynthia L Sears, Jessica Queen
Whittling down the bacterial subspecies that might drive colon cancer. Nature 628 (8007) (2024)
Cynthia L Sears, Jessica Queen
Whittling down the bacterial subspecies that might drive colon cancer. Nature 628 (8007) (2024)
Cynthia L Sears, Jessica Queen
Whittling down the bacterial subspecies that might drive colon cancer. Nature (2024)
Maxwell T White, Cynthia L Sears
The microbial landscape of colorectal cancer. Nature reviews. Microbiology (2023)
Jessica Queen, Fyza Shaikh, Cynthia L Sears
Understanding the mechanisms and translational implications of the microbiome for cancer therapy innovation. Nature cancer (2023)
Jessica Queen, Jada C Domingue, James Robert White, Courtney Stevens, Barath Udayasuryan, Tam T D Nguyen, Shaoguang Wu, Hua Ding, Hongni Fan, Madison McMann, Alina Corona, Tatianna C Larman, Scott S Verbridge, Franck Housseau, Daniel Joseph Slade, Julia L Drewes, Cynthia L Sears
Comparative Analysis of Colon Cancer-Derived Fusobacterium nucleatum Subspecies: Inflammation and Colon Tumorigenesis in Murine Models. mBio (2022)
Julia L Drewes, Jie Chen, Nicholas O Markham, Reece J Knippel, Jada C Domingue, Ada J Tam, June L Chan, Lana Kim, Madison McMann, Courtney Stevens, Christine M Dejea, Sarah Tomkovich, John Michel, James Robert White, Fuad Mohammad, Victoria L Campodónico, Cody N Heiser, Xinqun Wu, Shaoguang Wu, Hua Ding, Patricia J Simner, Karen C Carroll, Martha J Shrubsole, Robert A Anders, Seth T Walk, Christian Jobin, Fengyi Wan, D Borden Lacy, Franck Housseau, Ken S Lau, Cynthia L Sears
Human Colon Cancer-Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice. Cancer discovery 12 (8) (2022)
Elinor Zhou, Lin Wang, Celina N Santiago, Julie Nanavati, Samara Rifkin, Emma Spence, Linda M Hylind, Joell J Gills, Louis La Luna, David R Kafonek, David M Cromwell, Julia L Drewes, Cynthia L Sears, Francis M Giardiello, Gerard E Mullin, null null
Adult-Attained Height and Colorectal Cancer Risk: A Cohort Study, Systematic Review, and Meta-Analysis. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 31 (4) (2022)
Fyza Y Shaikh, Joell J Gills, Fuad Mohammad, James R White, Courtney M Stevens, Hua Ding, Juan Fu, Ada Tam, Richard L Blosser, Jada C Domingue, Tatianna C Larman, Jamie E Chaft, Jonathan D Spicer, Joshua E Reuss, Jarushka Naidoo, Patrick M Forde, Sudipto Ganguly, Franck Housseau, Drew M Pardoll, Cynthia L Sears
Murine fecal microbiota transfer models selectively colonize human microbes and reveal transcriptional programs associated with response to neoadjuvant checkpoint inhibitors. Cancer immunology, immunotherapy : CII 71 (10) (2022)
Jawara Allen, Axel Rosendahl Huber, Cayetano Pleguezuelos-Manzano, Jens Puschhof, Shaoguang Wu, Xinqun Wu, Charelle Boot, Aurelia Saftien, Heather M O'Hagan, Hao Wang, Ruben van Boxtel, Hans Clevers, Cynthia L Sears
Colon Tumors in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized Mice Do Not Display a Unique Mutational Signature but Instead Possess Host-Dependent Alterations in the APC Gene. Microbiology spectrum 10 (3) (2022)
Sheetal Parida, Shaoguang Wu, Sumit Siddharth, Guannan Wang, Nethaji Muniraj, Arumugam Nagalingam, Christina Hum, Panagiotis Mistriotis, Haiping Hao, C Conover Talbot, Konstantinos Konstantopoulos, Kathleen L Gabrielson, Cynthia L Sears, Dipali Sharma
A Procarcinogenic Colon Microbe Promotes Breast Tumorigenesis and Metastatic Progression and Concomitantly Activates Notch and β-Catenin Axes. Cancer discovery 11 (5) (2021)
Reece J Knippel, Julia L Drewes, Cynthia L Sears
The Cancer Microbiome: Recent Highlights and Knowledge Gaps. Cancer discovery 11 (10) (2021)
Yue Liu, Kai Fu, Eric M Wier, Yifan Lei, Andrea Hodgson, Dongqing Xu, Xue Xia, Dandan Zheng, Hua Ding, Cynthia L Sears, Jian Yang, Fengyi Wan
Bacterial genotoxin accelerates transient infection-driven murine colon tumorigenesis. Cancer discovery (2021)
Christina E DeStefano Shields, James R White, Liam Chung, Alyssa Wenzel, Jessica L Hicks, Ada J Tam, June L Chan, Christine M Dejea, Hongni Fan, John Michel, Ashley R Maiuri, Shruthi Sriramkumar, Ram Podicheti, Douglas B Rusch, Hao Wang, Angelo M DeMarzo, Sepideh Besharati, Robert A Anders, Stephen B Baylin, Heather M O'Hagan, Franck Housseau, Cynthia L Sears
Bacterial-Driven Inflammation and Mutant BRAF Expression Combine to Promote Murine Colon Tumorigenesis That Is Sensitive to Immune Checkpoint Therapy. Cancer discovery 11 (7) (2021)
Celina N Santiago, Samara Rifkin, Julia Drewes, Gerard E Mullin, Emma Spence, Linda M Hylind, Joell J Gills, David Kafonek, David M Cromwell, Louis La Luna, Francis Giardello, Cynthia L Sears, null null
Self-reported Metabolic Risk Factor Associations with Adenomatous, Sessile Serrated, and Synchronous Adenomatous and Sessile Serrated Polyps. Cancer prevention research (Philadelphia, Pa.) 14 (7) (2021)
Annemarie Boleij, Payam Fathi, William Dalton, Ben Park, Xinqun Wu, David Huso, Jawara Allen, Sepideh Besharati, Robert A Anders, Franck Housseau, Amanda E Mackenzie, Laura Jenkins, Graeme Milligan, Shaoguang Wu, Cynthia L Sears
G-protein coupled receptor 35 (GPR35) regulates the colonic epithelial cell response to enterotoxigenic Bacteroides fragilis. Communications biology 4 (1) (2021)
Jiajia Zhang, Cynthia L Sears
Antibiotic Use Impacts Colorectal Cancer: A Double-Edged Sword by Tumor Location? Journal of the National Cancer Institute (2021)
Fyza Y Shaikh, James R White, Joell J Gills, Taiki Hakozaki, Corentin Richard, Bertrand Routy, Yusuke Okuma, Mykhaylo Usyk, Abhishek Pandey, Jeffrey S Weber, Jiyoung Ahn, Evan J Lipson, Jarushka Naidoo, Drew M Pardoll, Cynthia L Sears
A Uniform Computational Approach Improved on Existing Pipelines to Reveal Microbiome Biomarkers of Nonresponse to Immune Checkpoint Inhibitors. Clinical cancer research : an official journal of the American Association for Cancer Research 27 (9) (2021)
Jessica Queen, Jiajia Zhang, Cynthia L Sears
Oral antibiotic use and chronic disease: long-term health impact beyond antimicrobial resistance and Clostridioides difficile. Gut microbes 11 (4) (2020)
Mary C Macedonia, Julia L Drewes, Nicholas O Markham, Alan J Simmons, Joseph T Roland, Paige N Vega, Cherie' R Scurrah, Robert J Coffey, Martha J Shrubsole, Cynthia L Sears, Ken S Lau
Clinically adaptable polymer enables simultaneous spatial analysis of colonic tissues and biofilms. NPJ biofilms and microbiomes 6 (1) (2020)
Nicolas J Llosa, Brandon Luber, Nicholas Siegel, Anas H Awan, Teniola Oke, Qingfeng Zhu, Bjarne R Bartlett, Laveet K Aulakh, Elizabeth D Thompson, Elizabeth M Jaffee, Jennifer N Durham, Cynthia L Sears, Dung T Le, Luis A Diaz, Drew M Pardoll, Hao Wang, Franck Housseau, Robert A Anders
Immunopathologic Stratification of Colorectal Cancer for Checkpoint Blockade Immunotherapy. Cancer immunology research 7 (10) (2019)
Cynthia L Sears
The who, where and how of fusobacteria and colon cancer. eLife 7 (2018)
Christine M Dejea, Payam Fathi, John M Craig, Annemarie Boleij, Rahwa Taddese, Abby L Geis, Xinqun Wu, Christina E DeStefano Shields, Elizabeth M Hechenbleikner, David L Huso, Robert A Anders, Francis M Giardiello, Elizabeth C Wick, Hao Wang, Shaoguang Wu, Drew M Pardoll, Franck Housseau, Cynthia L Sears
Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria. Science (New York, N.Y.) 359 (6375) (2018)