miR-328 mediates a metabolic shift in colon cancer cells by targeting SLC2A1/GLUT1.
S SantasusagnaI MorenoA NavarroC MuñozF MartinezR HernándezJ J CastellanoMariano MonzóPublished in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2018)
Our results show that miR-328 targets SLC2A1/GLUT1. We suggest that miR-328 may be involved in the orchestration of the Warburg effect in colon cancer cells. Furthermore, miR-328 expression is reduced in colon cancer patients and thus inversely correlates with the classically reported upregulated SLC2A1/GLUT1 expression in tumors.