Co-infection with distinct Trypanosoma cruzi strains induces an activated immune response in human monocytes.
Luísa M D MagalhãesLívia S A PassosEgler ChiariLúcia M C GalvãoCarolina C KohMarina L Rodrigues-AlvesRodolfo C GiunchettiKenneth John GollobWalderez Ornelas DutraPublished in: Parasite immunology (2019)
Our results show that the exacerbated response observed in co-infection with immune-polarizing strains is associated with a decreased frequency of co-infected cells, suggesting that the activated response favours parasite control. These findings may have implications for designing new Chagas disease preventive strategies.