The Role of Splicing Factors in Adipogenesis and Thermogenesis.
Yadanar Than NaingLei SunPublished in: Molecules and cells (2023)
Obesity is a significant global health risk that can cause a range of serious metabolic problems, such as type 2 diabetes and cardiovascular diseases. Adipose tissue plays a pivotal role in regulating energy and lipid storage. New research has underlined the crucial role of splicing factors in the physiological and functional regulation of adipose tissue. By generating multiple transcripts from a single gene, alternative splicing allows for a greater diversity of the proteome and transcriptome, which subsequently influence adipocyte development and metabolism. In this review, we provide an outlook on the part of splicing factors in adipogenesis and thermogenesis, and investigate how the different spliced isoforms can affect the development and function of adipose tissue.
Keyphrases
- adipose tissue
- insulin resistance
- type diabetes
- high fat diet induced
- health risk
- high fat diet
- cardiovascular disease
- genome wide
- mental health
- metabolic syndrome
- gene expression
- fatty acid
- drinking water
- skeletal muscle
- weight loss
- glycemic control
- risk assessment
- single cell
- copy number
- body mass index
- dna methylation
- genome wide identification