Mechanisms and direction of allocation bias in randomised clinical trials.

Asger Sand Paludan-MüllerDavid Ruben Teindl LaursenAsbjørn Hróbjartsson

Published in: BMC medical research methodology (2016)

Inadequate allocation concealment may exaggerate treatment effects in some trials while underestimate effects in others. Our hypothesis provides a theoretical overview of the main factors responsible for the direction of allocation bias.

Keyphrases

clinical trial
open label
randomized controlled trial
phase ii
phase iii
smoking cessation