Prognostic Value of Immunohistochemical Markers for Locally Advanced Rectal Cancer.
Anas TahaStephanie Taha-MehlitzStephanie PetzoldSergey L AchinovichDmitry Aleksandrovich ZinovkinBassey EnodienMd Zahidul Islam PranjolEldar A NadyrovPublished in: Molecules (Basel, Switzerland) (2022)
The aim of this study is to reveal the potential roles of apoptosis markers (Bcl2 and p53), proliferation markers (Ki-67 and CyclD1), and the neuroendocrine marker Chromogranin A as markers for the radioresistance of rectal cancer. Statistically significant differences were found in the expression of p53, Ki-67, and Chromogranin A in groups of patients with and without a favorable prognosis after radiotherapy. The survival analysis revealed that the marker of neuroendocrine differentiation, Chromogranin A, also demonstrated a high prognostic significance, indicating a poor prognosis. Markers of proliferation and apoptosis had no prognostic value for patients who received preoperative radiotherapy. Higher Chromogranin A values were predictors of poor prognosis. The results obtained from studying the Chromogranin A expression suggest that the secretion of biologically active substances by neuroendocrine cells causes an increase in tumor aggressiveness.
Keyphrases
- poor prognosis
- long non coding rna
- rectal cancer
- locally advanced
- cell cycle arrest
- oxidative stress
- early stage
- neoadjuvant chemotherapy
- signaling pathway
- cell death
- radiation therapy
- endoplasmic reticulum stress
- squamous cell carcinoma
- single cell
- radiation induced
- risk assessment
- lymph node
- gene expression
- cell proliferation
- dna damage
- cancer stem cells
- binding protein
- human health