Antibiotics versus placebo in adults with CT-confirmed uncomplicated acute appendicitis (APPAC III): randomized double-blind superiority trial.

Paulina SalminenSuvi SippolaJussi HaijanenPia NordströmTuomo RantanenTero RautioVille J SallinenEliisa LöyttyniemiSaija HurmeVille TammilehtoJohanna LaukkarinenHeini SavolainenSanna MeriläinenAri LeppäniemiJuha Grönroos

Published in: The British journal of surgery (2022)

The lack of antibiotic superiority statistically suggests that a non-inferiority trial against placebo is warranted in adults with CT-confirmed mild appendicitis. Registration number: EudraCT 2015-003634-26 (https://eudract.ema.europa.eu/eudract-web/index.faces), NCT03234296 (http://www.clinicaltrials.gov).

Keyphrases

phase iii
double blind
placebo controlled
phase ii
clinical trial
open label
study protocol
image quality
dual energy
computed tomography
contrast enhanced
magnetic resonance imaging
positron emission tomography
randomized controlled trial
urinary tract infection