Sodium-glucose cotransporter 2 inhibitor effects on heart failure hospitalization and cardiac function: systematic review.
Roy RasalamJohn J AthertonGary DeedMichael Molloy-BlandNeale CohenAndrew SindonePublished in: ESC heart failure (2021)
Sodium-glucose cotransporter 2 inhibitors reduce HHF regardless of T2DM status, and reversal of adverse left ventricular remodelling likely contributes to this efficacy. Hypothesis-driven mechanistic trials remain sparse, although numerous trials are planned or ongoing.
Keyphrases
- heart failure
- systematic review
- left ventricular
- cardiac resynchronization therapy
- meta analyses
- hypertrophic cardiomyopathy
- acute myocardial infarction
- mitral valve
- atrial fibrillation
- aortic stenosis
- left atrial
- emergency department
- randomized controlled trial
- adipose tissue
- insulin resistance
- transcatheter aortic valve replacement
- weight loss